|
KMID : 0363219740120030199
|
|
Korean Journal of Dermatology
1974 Volume.12 No. 3 p.199 ~ p.202
|
|
|
Treatment of Erythroplasia of Queyrat with Topical 5-Fluorouracil Cream
|
|
晉洪商/Chin, Hong Sang
趙吉衍/禹泰河/Cho, Kil Yun/Woo, Tae Ha
|
|
|
Abstract
|
|
|
Erythroplasia of Queyrat is a precancercus lesion, usually located to glans penis or prepuce. It is characterized by a slowly developing, circumscribed, usually velvety and shiny patch.
The etiology was unknown, but it is extremely rare in those circumcised in early infancy. It had been suggested that pi moiis had some etiologic importance.
The typical case of Erythroplasia of Queyrat is presented.
A 46 year old man had 4 months history of dark-brownish pea sized maculopapular rashes on sulcus of glans penis and prepuce associated with mild itching, which was increased in number day by day.
He had a phimosis. On exam nation, there are sharply defined,. slightly elevated, pea sized dark-brownish maculopapular rashes over erythematous infiltrated base on sulcus of glans penis and prepuce, which have moist and velvety appearance.
A biopsy was performed from sulcus of glans penis. Histopathologically, there was acanthosis, with in epidermis many cells are vacuolated and showed individual cell keratinization. Epithelial cell sho,\-ed marked atypic, variation in nuclear size and there was intercellular, intracellular edema.
The lesion was treated with topical application of 5% 5-fluorouracil twice daily 2 weeks and thereafter for 4 weeks.
2 months after treatment, r-o ery-th r_~nlastic lesion was found and 3 months after treatment, rebiopsy was performed which showed marked improvement histopathologically.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|